An Antithrombin-Heparin Complex Increases the Anticoagulant Activity of Fibrin Clots

نویسندگان

  • Lesley J. Smith
  • Tracy Anne Mewhort-Buist
  • Leslie R. Berry
  • Anthony K. C. Chan
چکیده

Clotting blood contains fibrin-bound thrombin, which is a major source of procoagulant activity leading to clot extension and further activation of coagulation. When bound to fibrin, thrombin is protected from inhibition by antithrombin (AT) + heparin but is neutralized when AT and heparin are covalently linked (ATH). Here, we report the surprising observation that, rather than yielding an inert complex, thrombin-ATH formation converts clots into anticoagulant surfaces that effectively catalyze inhibition of thrombin in the surrounding environment.

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عنوان ژورنال:

دوره 2008  شماره 

صفحات  -

تاریخ انتشار 2008